A Multi-Variate Predictability Framework to Assess Invasive Cardiac Activity and Interactions During Atrial Fibrillation

Autores

Alcaine, A; Mase, M; Cristoforetti, A; Ravelli, F; Nollo, G; Laguna, P; Martinez, JP; Faes, L

Revista

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Año: 2017 Volumen: 64 (5) Páginas: 1157-1168

Editor:

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

DOI:

10.1109/TBME.2016.2592953

Resumen

Objective: This study introduces a predictability framework based on the concept of Granger causality (GC), in order to analyze the activity and interactions between different intracardiac sites during atrial fibrillation (AF). Methods: GC-based interactions were studied using a three-electrode analysis scheme with multi-variate autoregressive models of the involved preprocessed intracardiac signals. The method was evaluated in different scenarios covering simulations of complex atrial activity as well as endocardial signals acquired from patients. Results: The results illustrate the ability of the method to determine atrial rhythm complexity and to track andmap propagation during AF. Conclusion: The proposed framework provides information on the underlying activation and regularity, does not require activation detection or postprocessing algorithms and is applicable for the analysis of any multielectrode catheter. Significance: The proposed framework can potentially help to guide catheter ablation interventions of AF.

Palabras clave

Atrial ; fibrillation ; (AF) ; bipolar ; electrograms ; (EGMs) ; Granger ; causality ; (GC) ; multielectrode ; catheters ; multi-variate ; autoregressive ; (MVAR) ; modeling

Afiliación

Alcaine, A (Reprint Author), Univ Zaragoza, IIS Aragon, BSICoS Grp, Aragon Inst Engn Res, Zaragoza 50018, Spain.
Alcaine, Alejandro; Laguna, Pablo; Pablo Martinez, Juan, Univ Zaragoza, IIS Aragon, BSICoS Grp, Aragon Inst Engn Res, Zaragoza 50018, Spain.
Alcaine, Alejandro; Laguna, Pablo; Pablo Martinez, Juan, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, Madrid 28029, Spain.
Mase, Michela; Cristoforetti, Alessandro; Ravelli, Flavia, Univ Trento, Dept Phys, Trento, Italy.
Nollo, Giandomenico; Faes, Luca, Univ Trento, Dept Ind Engn, IRCS FBK & BIOtech, Trento, Italy.