Coronary artery disease diagnosis by means of heart rate variability analysis using respiratory information


Hernando, D; Kahonen, M; Lazaro, J; Lehtinen, R; Nieminen, T; Nikus, K; Lehtimaki, T; Bailon, R; Viik, J


EMBEC & NBC 2017

Año: 2018 Volumen: 65 Páginas: 270-273






Univ Tampere, BioMediTech Inst; Tampere Univ Technol, BioMediTech Inst; Finnish Soc Med Phys & Med Engn; Int Org Med & Biol Engn; European Alliance Med & Biol Engn & Sci; EMBEC Soc


Heart rate variability (HRV) analysis during exercise has been used to evaluate cardiovascular response to the stress of exercise, which may offer additional value than in rest condition. To properly analyze HRV during exercise, several challenges need to be addressed, such as including respiratory information and removing the dependance with the mean heart rate (HR) level. The objective of this work is to extract parameters from HRV analysis and respiratory information during exercise to evaluate their capability of diagnose coronary artery disease (CAD). Significant differences in mean HR were found due to medication effect in patients with CAD. By correcting the HRV parameters by mean HR, this effect is minimized. Power related to high frequency, when guided by respiration, results to have the best diagnosis capability (AUC > 0.7).

Palabras clave

Exercise ; test ; respiratory ; rate ; CAD ; diagnosis


Hernando, D (Reprint Author), Univ Zaragoza, IIS Aragon, BSICoS Grp, I3A, Zaragoza, Spain.
Hernando, D (Reprint Author), CIBER, Madrid, Spain.
Hernando, D.; Bailon, R., Univ Zaragoza, IIS Aragon, BSICoS Grp, I3A, Zaragoza, Spain.
Hernando, D.; Bailon, R., CIBER, Madrid, Spain.
Kahonen, M., Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.
Kahonen, M.; Nikus, K.; Lehtimaki, T., Univ Tampere, Fac Med & Life Sci, Tampere, Finland.
Lazaro, J., Katholieke Univ Leuven, ESAT, STADIUS, Leuven, Belgium.
Lazaro, J., IMEC, Leuven, Belgium.
Lehtinen, R., Tampere Univ Appl Sci, Tampere, Finland.
Nieminen, T., Univ Helsinki, Dept Internal Med, Helsinki, Finland.
Nikus, K., Tampere Univ Hosp, Heart Ctr, Tampere, Finland.
Lehtimaki, T., Univ Tampere, Dept Clin Chem, Fimlab Labs, Tampere, Finland.
Viik, J., Tampere Univ Technol, BioMediTech Inst, Tampere, Finland.
Viik, J., Tampere Univ Technol, Fac Biomed Sci & Engn, Tampere, Finland.